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Research
Our group began to explore unconventional routes to prepare a new form of dipica and its metal complexes to use them as catalysts. Koneramines are the tridentate ligands that possess two Npy donors (N1 and N3) and tertiary amine nitrogen donor N2 in addition to tertiary amine on the backbone (N4) which cannot participate in coordination. Substitution on the N4 can tune electronic and steric properties of the ligand in order to show a wide range of applications.
A highly flexible variant of koneramines (a tridentate ligand) having hard (N) and soft donors (P) centre has been synthesized. This ligand is flexible enough to stabilize both higher and lower oxidation states of metal centre [e.g. Cu(I) and Cu(II)]. Complexes of Cu(II), Ni(II), Co(II), Zn(II) in addition to Ru(II) and Pd(II) were isolated. These complexes are promising candidate to undergo various post-synthetic modifications to show a wide range of applications like hydride donors, redox catalysts, activating the small molecules, etc.
Objective:
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Synthesis of bioinspired tridentate koneramine ligand
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Metal Hydride
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Chiral resolution
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Biological studies
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Catalysis
Project 1: Hemiparetic koneramine NNP ligand comprising strategic hard and soft donors: transition metal complexes, CS2 activation and therapeutic potential (Published)
Project 2: Air-Stable Copper(I) Borohydride for Carbon Disulfide Mitigation through Sustainable Hydride Transfer (published)
Project 3: Synthesis of PNP ligand and its application towards CO2 and CS2 activation. (under revision)
Project 4: A Dansyl-Appended Koneramine as a Robust and Reversible Fluorescent Probe for Copper(II) Detection (under revision)
Project 5: Synthesis of Dihydrobenzothiazoles and its metal complexes for sequestration and activation of SO2. (manuscript under preparation)
Project 6: Structure-Activity Relationship in Koneramine Metal Complexes: Influence of N4 alkyl Functionalization in Modulating Antimicrobial Properties (manuscript under preparation)
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